| Rank | Title | Weekend | Gross |
|---|---|---|---|
| 1 | The Hangover (2009) | $33.4M | $105M |
| 2 | Up (2009) | $30.5M | $187M |
| 3 | The Taking of Pelham 1 2 3 (2009) | $25M | $25M |
| 4 | Night at the Museum: Battle of the Smithsonian (2009) | $9.6M | $143M |
| 5 | Land of the Lost (2009) | $9.15M | $35M |
| 6 | Imagine That (2009) | $5.7M | $5.7M |
| 7 | Star Trek (2009) | $5.6M | $232M |
| 8 | Terminator Salvation (2009) | $4.7M | $114M |
| 9 | Angels & Demons (2009) | $4.2M | $123M |
| 10 | Drag Me to Hell (2009) | $3.86M | $35.1M |